FOXP2 expression during brain development coincides with.
Recently, FOXP2, a member of the Foxp subfamily, was identified as the first gene to be linked to an inherited form oflanguage and speech disorder. The discovery of a mutation in FOXP2 in a family with a speech and language disorder opened a new window to understanding the genetic cascades and neural circuits that underlie speech and language via molecular approaches.
Underactivation in the motor cortex accounts for the difficulty in speech Overactivation in the pre-motor cortex and Broca's area may be compensatory or may be indicative of an abnormality While language is undoubtedly complex, the data does suggest that FOXP2 is involved in the.
Neural basis of an inherited speech and language disorder. Proc Natl Acad Sci USA. 1998; 95: 12695-12700 View in Article.
Furthermore, this task has also been shown to be a reliable phenotypic marker in individuals with genetically inherited speech and language disorder (Watkins et al., 2002). Nonword repetition is the core task that co-segregates affected vs unaffected KE family members who present with an inherited mutation in FOXP2, resulting in childhood apraxia of speech (CAS) and language disorder ( Watkins.
Studies on the neural basis of normal language development have focused on different aspects of the language system, namely (1) phonological processes concerning suprasegmental information (i.e., prosody, sentence melody) and segmental information (phonemes, i.e., speech sounds relevant for word meaning), (2) lexical-semantic processes (i.e., processes that deal with word forms and word.
Analyses of brain structure in genetic speech and language disorders provide an opportunity to identify neurobiological phenotypes and further elucidate the neural bases of language and its.
We have studied a unique three-generation pedigree, KE, in which a severe speech and language disorder is transmitted as an autosomal-dominant monogenic trait4. Our previous work mapped the locus.